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Cytotec tablets

Cytotec protects the gastroduodenal mucosa by inhibiting basal, stimulated and nocturnal acid secretion and by reducing the volume of gastric secretions, the proteolytic activity of the gastric fluid, and increasing bicarbonate and mucus secretion. Misoprostol, sold under the brandname Cytotec among others, is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to .
Cytotec (Misoprostol) is a drug that was originally developed as a medicinal product to protect the cavity of the stomach and duodenum from excessively rapid reabsorption of the mucous protective layer. Cytotec oral tablets contain either mcg or mcg of misoprostol, a synthetic prostaglandin E 1 analog. Misoprostol contains approximately equal amounts of the two diastereomers presented below with their enantiomers indicated by (±): Misoprostol is a water-soluble, viscous liquid. Cytotec oral tablets contain either mcg or mcg of misoprostol, a synthetic prostaglandin E 1 analog.. Misoprostol contains approximately equal amounts of the two diastereomers presented below with their enantiomers indicated by (±).

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Physicians and patients should remain alert for ulceration, even in the absence of gastrointestinal symptoms, and, where appropriate, endoscopy and biopsy should be carried out before use to ensure that malignant disease is absent in the upper gastrointestinal tract. So if possible, have an ultrasound made about one week after the abortion to make sure that the pregnancy has ended. In countries where abortion is illegal, Misoprostol alone can be used to cause an abortion. An ultrasound shows whether the pregnancy is in the womb and the length number of weeks of a woman's pregnancy. Cytotec tablets Инструкция по применению препарата Сайтотек. Как использовать таблетки Сайтотек для прерывания беременности, отзывы врачей.  В жизни многих женщин случается незапланированная беременность, требующая принятия ответственного и нелёгкого решения. С целью избежания механического аборта следует обратить внимание на медикаментозный вариант, для осуществления которого используются специальные препараты. Cytotec Tablet содержит следующие активные ингредиенты: Misoprostol.  Cytotec Tablet - Использование, состав, побочные эффекты и отзывы. Таблетки для медикаментозного прерывания беременности Cytotec/Сайтотек: инструкция по применению. Сайтотек изначально разрабатывался как лекарственный препарат для защиты полости желудка и двенадцатиперстной кишки от чрезмерно быстрого рассасывания слизистого защитного слоя. Данное лекарство стимулируют выработку слизи, а вместе с этим подавляет синтез пепсина, который является основой желудочного сока.

When taking Cytotec for an abortion , the dosage is strictly selected by the doctor while taking into account the physiological state of the patient, age, and a number of pregnancies. Cytotec is dispensed as a single dose equal to mcg 1 tablet via standard packing. The effects of Cytotec begin to take action within 30 minutes. Over the next 6 hours, a woman has stimulated contractions, and the cervix dilates.

This process ends with a high amount of bleeding from the vagina, in which the egg leaves. If total vaginal bleeding exceeds the use of two traditional gaskets, an ambulance should be called because this is abnormal.

Alcohol should not be consumed while taking Cytotec because this can provoke more bleeding. An overdose with Cytotec does not cause any irreversible effects within the body. Cytotec should also not be consumed with antacid group drugs reduces the bioavailability of prostaglandin.

Use of Cytotec is contraindicated in minors as well as women who use a particular type of contraception i. Cytotec affects reaction rate. Therefore, at least 6 hours should pass after Cytotec before getting behind the wheel. Moreover, when taking Cytotec tablets for an abortion, in rare instances, this can be accompanied by the following side effects:.

Symptomatic treatment may be required to eliminate the adverse effects of Cytotec. However, in most cases, unpleasant symptoms disappear on their own within hours, which is explained by a gradual decrease in prostaglandin concentration. The total half-life of Cytotec is 18 hours. Cytotec is available only as a unit-of-use package that includes a leaflet containing patient information.

See Patient Information at the end of this labeling. Cytotec has not been shown to interfere with the beneficial effects of aspirin on signs and symptoms of rheumatoid arthritis. Cytotec does not exert clinically significant effects on the absorption, blood levels, and antiplatelet effects of therapeutic doses of aspirin.

Cytotec has no clinically significant effect on the kinetics of diclofenac or ibuprofen. Prostaglandins such as Cytotec may augment the activity of oxytocic agents, especially when given less than 4 hours prior to initiating oxytocin treatment.

Concomitant use is not recommended. A reversible increase in the number of normal surface gastric epithelial cells occurred in the dog, rat, and mouse.

No such increase has been observed in humans administered Cytotec for up to 1 year. An apparent response of the female mouse to Cytotec in long-term studies at to times the human dose was hyperostosis, mainly of the medulla of sternebrae.

Hyperostosis did not occur in long-term studies in the dog and rat and has not been seen in humans treated with Cytotec. There was no evidence of an effect of Cytotec on tumor occurrence or incidence in rats receiving daily doses up to times the human dose for 24 months. Similarly, there was no effect of Cytotec on tumor occurrence or incidence in mice receiving daily doses up to times the human dose for 21 months.

The mutagenic potential of Cytotec was tested in several in vitro assays, all of which were negative. Misoprostol, when administered to breeding male and female rats at doses 6. These findings suggest the possibility of a general adverse effect on fertility in males and females. Congenital anomalies sometimes associated with fetal death have been reported subsequent to the unsuccessful use of misoprostol as an abortifacient, but the drug's teratogenic mechanism has not been demonstrated.

Several reports in the literature associate the use of misoprostol during the first trimester of pregnancy with skull defects, cranial nerve palsies, facial malformations, and limb defects. Cytotec is not fetotoxic or teratogenic in rats and rabbits at doses and 63 times the human dose, respectively. Cytotec may endanger pregnancy may cause abortion and thereby cause harm to the fetus when administered to a pregnant woman.

Cytotec may produce uterine contractions, uterine bleeding, and expulsion of the products of conception.

Abortions caused by Cytotec may be incomplete. If a woman is or becomes pregnant while taking this drug to reduce the risk of NSAID-induced ulcers, the drug should be discontinued and the patient apprised of the potential hazard to the fetus. Cytotec can induce or augment uterine contractions. Vaginal administration of Cytotec, outside of its approved indication, has been used as a cervical ripening agent, for the induction of labor and for treatment of serious postpartum hemorrhage in the presence of uterine atony.

Uterine activity and fetal status should be monitored by trained obstetrical personnel in a hospital setting. The risk of uterine rupture associated with misoprostol use in pregnancy increases with advancing gestational ages and prior uterine surgery, including Cesarean delivery.

Grand multiparity also appears to be a risk factor for uterine rupture. The use of Cytotec outside of its approved indication may also be associated with meconium passage, meconium staining of amniotic fluid, and Cesarean delivery.

Maternal shock, maternal death, fetal bradycardia, and fetal death have also been reported with the use of misoprostol. Cytotec should not be used in the third trimester in women with a history of Cesarean section or major uterine surgery because of an increased risk of uterine rupture. Cytotec should not be used in cases where uterotonic drugs are generally contraindicated or where hyperstimulation of the uterus is considered inappropriate, such as cephalopelvic disproportion, grand multiparity, hypertonic or hyperactive uterine patterns, or fetal distress where delivery is not imminent, or when surgical intervention is more appropriate.

The effect of Cytotec on later growth, development, and functional maturation of the child when Cytotec is used for cervical ripening or induction of labor has not been established.

Information on Cytotec's effect on the need for forceps delivery or other intervention is unknown. The use of Cytotec misoprostol for the management of postpartum hemorrhage has been associated with reports of high fevers greater than 40 degrees Celsius or degrees Fahrenheit , accompanied by autonomic and central nervous system effects, such as tachycardia, disorientation, agitation, and convulsions.

These fevers were transient in nature. Supportive therapy should be dictated by the patient's clinical presentation. Misoprostol is rapidly metabolized in the mother to misoprostol acid, which is biologically active and is excreted in breast milk. There are no published reports of adverse effects of misoprostol in breast-feeding infants of mothers taking misoprostol. Caution should be exercised when misoprostol is administered to a nursing woman. Safety and effectiveness of Cytotec in pediatric patients have not been established.

In subjects receiving Cytotec or mcg daily in clinical trials, the most frequent gastrointestinal adverse events were diarrhea and abdominal pain. Rare instances of profound diarrhea leading to severe dehydration have been reported.

Patients with an underlying condition such as inflammatory bowel disease, or those in whom dehydration, were it to occur, would be dangerous, should be monitored carefully if Cytotec is prescribed. The incidence of diarrhea can be minimized by administering after meals and at bedtime, and by avoiding coadministration of Cytotec with magnesium-containing antacids.

Women who received Cytotec during clinical trials reported the following gynecological disorders: Postmenopausal vaginal bleeding may be related to Cytotec administration.

If it occurs, diagnostic workup should be undertaken to rule out gynecological pathology. There were no significant differences in the safety profile of Cytotec in approximately ulcer patients who were 65 years of age or older compared with younger patients.

However, there were no significant differences between the incidences of these events for Cytotec and placebo. The following adverse events were infrequently reported. Causal relationships between Cytotec and these events have not been established but cannot be excluded:. Body as a whole: The toxic dose of Cytotec in humans has not been determined. Cumulative total daily doses of mcg have been tolerated, with only symptoms of gastrointestinal discomfort being reported.

In animals, the acute toxic effects are diarrhea, gastrointestinal lesions, focal cardiac necrosis, hepatic necrosis, renal tubular necrosis, testicular atrophy, respiratory difficulties, and depression of the central nervous system. Clinical signs that may indicate an overdose are sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia. Symptoms should be treated with supportive therapy.

It is not known if misoprostol acid is dialyzable. However, because misoprostol is metabolized like a fatty acid, it is unlikely that dialysis would be appropriate treatment for overdosage. The recommended adult oral dose of Cytotec for reducing the risk of NSAID-induced gastric ulcers is mcg four times daily with food. If this dose cannot be tolerated, a dose of mcg can be used.

Cytotec should be taken with a meal, and the last dose of the day should be at bedtime. Adjustment of the dosing schedule in renally impaired patients is not routinely needed, but dosage can be reduced if the mcg dose is not tolerated.

Cytotec mcg tablets are white, hexagonal, with SEARLE debossed above and debossed below the line on one side and a double stomach debossed on the other side; supplied as:. This product's label may have been updated. For current full prescribing information, please visit www.

Cytotec can cause abortion sometimes incomplete which could lead to dangerous bleeding and require hospitalization and surgery , premature birth, or birth defects. It is also important to avoid pregnancy while taking this medication and for at least one month or through one menstrual cycle after you stop taking it.

Cytotec may cause the uterus to tear uterine rupture during pregnancy. The risk of uterine rupture increases as your pregnancy advances and if you have had surgery on the uterus, such as a Cesarean delivery. If you become pregnant during Cytotec therapy, stop taking Cytotec and contact your physician immediately.

Remember that even if you are on a means of birth control it is still possible to become pregnant. Should this occur, stop taking Cytotec and contact your physician immediately. In most cases these problems develop during the first few weeks of therapy and stop after about a week.

You can minimize possible diarrhea by making sure you take Cytotec with food. Because these side effects are usually mild to moderate and usually go away in a matter of days, most patients can continue to take Cytotec. Do not give Cytotec to anyone else.

Congenital anomalies sometimes associated with fetal death have been reported subsequent to the unsuccessful use of misoprostol as an abortifacient, but the drug's teratogenic mechanism has not been demonstrated. In such patients it is advised that Cytotec should only be used if the patient: Prostaglandin D 2 Treprostinil Antagonists: Misoprostol binds to and stimulates prostaglandin EP2 receptorsprostaglandin EP3 receptor and prostaglandin EP4 receptor but not Prostaglandin EP1 receptor and therefore is expected to have a more restricted range of physiological and potentially toxic actions than prostaglandin E2 or other analogs which activate all four prostaglandin receptors, cytotec tablets. There is no evidence that Cytotec has adverse effects on glucose metabolism in human volunteers or patients with diabetes mellitus. Cytotec tablets
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